AustralieFrV1, Main, Exploration, bibRecord, 00A404

The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation : Influence of tumor site, type of mutation, and adjuvant treatment

Identifieur interne : 00A404 ( Main/Exploration ); précédent : 00A403; suivant : 00A405

The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation : Influence of tumor site, type of mutation, and adjuvant treatment

Auteurs : Antonio Russo [Italie, Australie, Royaume-Uni, France] ; Viviana Bazan ; Barry Iacopetta ; David Kerr ; Thierry Soussi ; Nicola Gebbia

Source :

Journal of clinical oncology [ 0732-183X ] ; 2005.

RBID : Pascal:05-0471353

Descripteurs français

Pascal (Inist)
- Cancer colorectal, Gène TP53, International, Pronostic, Gène suppresseur tumeur, Mutation, Génétique, Traitement adjuvant, Cancérologie, Gène p53.
Wicri :
- topic : Génétique.

English descriptors

KwdEn :
- Adjuvant treatment, Cancerology, Colorectal cancer, Genetics, International, Mutation, Prognosis, TP53 Gene, Tumor suppressor gene.

Abstract

Purpose The aims of the TP53 Colorectal Cancer (CRC) International Collaborative Study were to evaluate the possible associations between specific TP53 mutations and tumor site, and to evaluate the prognostic and predictive significance of these mutations in different site, stage, and treatment subgroups Patients and Methods A total of 3,583 CRC patients from 25 different research groups in 17 countries were recruited to the study Patients were divided into three groups according to site of the primary tumor TP53 mutational analyses spanned exons 4 to 8 Results TP53 mutations were found in 34% of the proximal colon tumors and in 45% of the distal colon and rectal tumors They were associated with lymphatic invasion in proximal tumors In distal colon tumors, deletions causing loss of amino acids were associated with worse survival In proximal colon tumors, mutations in exon 5 showed a trend toward statistical significance (P < 05) when overall survival was considered Dukes' C tumors with wild-type TP53 and those with mutated TP53 (proximal tumors) showed significantly better prognosis when treated with adjuvant chemotherapy Conclusion Analysis of TP53 mutations from a large cohort of CRC patients has identified tumor site, type of mutation, and adjuvant treatment as important factors in determining the prognostic significance of this genetic alteration.

Affiliations:

Australie, France, Italie, Royaume-Uni
Angleterre, Oxfordshire, Sicile, Île-de-France
Oxford, Palerme, Paris
Université d'Oxford, Université de Palerme

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Purpose The aims of the TP53 Colorectal Cancer (CRC) International Collaborative Study were to evaluate the possible associations between specific TP53 mutations and tumor site, and to evaluate the prognostic and predictive significance of these mutations in different site, stage, and treatment subgroups Patients and Methods A total of 3,583 CRC patients from 25 different research groups in 17 countries were recruited to the study Patients were divided into three groups according to site of the primary tumor TP53 mutational analyses spanned exons 4 to 8 Results TP53 mutations were found in 34% of the proximal colon tumors and in 45% of the distal colon and rectal tumors They were associated with lymphatic invasion in proximal tumors In distal colon tumors, deletions causing loss of amino acids were associated with worse survival In proximal colon tumors, mutations in exon 5 showed a trend toward statistical significance (P < 05) when overall survival was considered Dukes' C tumors with wild-type TP53 and those with mutated TP53 (proximal tumors) showed significantly better prognosis when treated with adjuvant chemotherapy Conclusion Analysis of TP53 mutations from a large cohort of CRC patients has identified tumor site, type of mutation, and adjuvant treatment as important factors in determining the prognostic significance of this genetic alteration.</div>
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The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation : Influence of tumor site, type of mutation, and adjuvant treatment

The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation : Influence of tumor site, type of mutation, and adjuvant treatment

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri